Fisetin is a polyphenol found in fruits such as strawberries (160 mg/kg), apples (27mg/kg) and persimmon (10 mg/kg), as well as in some medicinal plants. It has multiple biological benefits, including the inhibition of cell proliferation, neuroprotection, bone protection and suppression of inflammation.
But it’s two most extraordinary properties are its ability to both destroy senescent cells that pervade the body and aid in activating autophagy, which enables cells to devour their own waste products. Several studies have shown it helps extend longevity and reduce markers of senescence in humans.
Its hydrophobic nature means it easily penetrates cells via the cell membrane. It then encourages the self-destruction of abnormal cells (such as senescent cells) by activating various characteristic proteins.
One of its main advantages over other senolytics is its ability to reduce the proportion of senescent immune cells (T lymphocytes and NK cells). Since immune cells are themselves important for cleaning out senescent cells, this makes fisetin even more effective. This study highlights its senolytic properties and impact on longevity: Fisetin is a senotherapeutic that extends health and lifespan.
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Fisetin is a rare product that acts on three key processes associated with aging: the increase in senescent cells, inactivation of the autophagy process, and the decline in neural communication. People looking to combat the aging process often turn to fisetin due to its well documented advantages.
How Senescent Cells Damage the Body and How Senotherapy Works
In 2014, there was a major scientific advance in the fight against aging: researchers identified totally depleted cells in the tissues of individuals over 40 years old.
Spread throughout the body’s tissues, these so-called senescent cells are defective, unable to fulfill their function. And, although they no longer work properly, they are not eliminated from the body and thus accumulate pathologically in the milieu, according to research.
Uncommon in young people, these senescent cells increase with age, particularly in adipose tissue, skeletal muscle, blood vessels, the brain, the kidneys and skin.
Unfortunately, senescent cells are not content to simply stay-put; they also impede the activity of neighboring healthy cells by continually releasing pro-inflammatory substances (IL-1, IL-6 and IL-8), vesicles and insoluble proteins (fibronectin, collagen) in the extracellular milieu.
But these substances don’t just signal to other cells the advanced state of deterioration they’re in; they affect the function of nearby healthy cells. And numerous studies have shown the number of senescent cells in the body is directly linked to the aging process and the development of age-related diseases.
Even a low level of senescent cells is enough to wreak havoc in healthy tissue and trigger a number of age-related health problems: systemic inflammation, arthritis, atherosclerosis, chronic diseases, sarcopenia, cataracts, insulin resistance, vascular hyporeactivity and more.
That brings us to senotherapy, an early-stage research field looking into the development of therapeutic agents and techniques that will target cellular senescence. Fisetin supplements are one of the options that show great promise in combating the negative effects of senescent cells.